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Tildren® (Rx)

(tiludronate disodium) 500mg

Tildren® is indicated for the control of clinical signs associated with navicular syndrome in horses.

Navicular syndrome is the most common cause of chronic forelimb lameness in performance horses. It is a degenerative process instigated by mechanical forces.


  • Restores balance to the process of bone remodeling
  • Decrease mineral loss and slow the rate of bone turnover
  • Alleviate pain induced by abnormal osteolysis

Tildren® Activity

Tildren® restores balance to the process of bone remodeling.

Tildren® partially inhibits bone resorption by:

  • Inhibiting osteoclastic activity (Destroys excess osteoclasts)
  • Not modifying osteoblastic activity (Bone formation remains the same)
  • Slowing the rate of bone turnover (Bone resorption is slowed, but not stopped)

Tildren® mode of action:


1 Inhibition of osteoclast pump

2 Disruption of the osteoclast cytoskeleton

3 Creation of a cytotoxin

Safety Recommendations


  • Tildren®-related clinical signs of colic are well characterized and self-limiting


  • Do not use NSAIDs concurrently with Tildren®
  • Concurrent use may increase the risk of renal toxicity and acute renal failure


  • Horses should be well hydrated prior to administration


  • Do not use in horses with known hypersensitivity to tiludronate disodium or to mannitol.
  • Do not use in horses with impaired renal function or with a history of renal disease.
  • Bisphosphonates are excreted by the kidney; therefore, conditions causing renal impairment may increase plasma bisphosphonate concentrations resulting in an increased risk for adverse reactions.


  • The safe use of Tildren® has not been evaluated in horses less than 4 years of age.
  • Bisphosphonates should not be used in pregnant or lactating mares, or mares intended for breeding.

Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Always consult with your veterinarian if you suspect your horse may have navicular syndrome as the clinical signs can vary.

Tildren® is a registered trademark of Ceva Santé Animale, S.A.

Available Pack Sizes

Product Code Unit Size Case
1TIL004 500mg 12

Documents to Download

*Rx. Federal law restricts this product to use by or on the order of a licensed veterinarian

Use Medicines Responsibly.
See for information about our full range of products.

For complete product information, including contra-indications, see the datasheet.

Contact Us - US

Bimeda® US - Head Office
One Tower Lane, Suite 2250,
Oakbrook Terrace, IL 60181
Phone: 1 888 524 6332